PerkinElmer

Metabolic Disease

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Metabolic diseases like diabetes are increasingly widespread, and research for this class of diseases relies on discovering and quantifying biomarkers to elucidate underlying mechanisms and uncover novel drug targets. Our portfolio of metabolic assays are well suited for metabolic disease research in vitro, in vivo, and in situ, and offer novel tools for your research workflow from start to finish.

Metabolic diseases are systemic and manifest with a variety of biological changes, from autophagy dysfunction to altered blood coagulation. For easy detection of a wide range of metabolic biomarkers, we offer fast and pre-validated metabolic assay reagents, kits, and imaging systems. For targeted binding studies, we also provide target-specific radiolabeled reagents.

Our products for metabolic disease research include:

  • LANCE? TR-FRET technology
  • AlphaLISA? immunoassay kits
  • Alpha reagents for AlphaLISA
  • DELFIA? TRF technology
  • Cellular, tissue, and in vivo imaging systems
  • Target-specific radiolabeled ligands, carbohydrates, lipids, and steroids

The range of tools offered allows for the detection and quantitation of many key biomolecules in metabolic disease research. Gain precise insight on disease biomarkers like c-reactive protein, fibrinogen, IGF, FGF, insulin and glucagon, leptin and ghrelin, adiponectin, and factor VIII.

Products & Services (130)
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Product Type
  • Instruments (1)
  • Reagents (126)
  • Software and Informatics (3)
Assay Target
  • Acetyl CoA carboxylase (1)
  • Adiponectin (3)
  • Albumin (5)
  • AMPKα1/2 (1)
  • ApoA1 (4)
  • ApoB (2)
  • ApoC3 (2)
  • ApoE (2)
  • AST (1)
  • BMP-9 (1)
  • C-peptide (2)
  • CCL2 (1)
  • Corticosterone (2)
  • Cortisol (3)
  • ERK1/2 (1)
  • Factor VIII (1)
  • FSH (3)
  • Ghrelin (4)
  • GLP-1 (2)
  • Glucagon (3)
  • Growth Hormone (1)
  • hCG (3)
  • HO-1 (1)
  • HO-2 (1)
  • IGF1 (5)
  • IGF2 (1)
  • Insulin (4)
  • JNK1/2 (1)
  • KIM-1 (1)
  • LDH (1)
  • Leptin (5)
  • MANF (2)
  • MBNL1 (1)
  • NNMT (1)
  • Osteoprotegerin (1)
  • PCSK9 (1)
  • PIGF (1)
  • PON1 (1)
  • PON2 (1)
  • Progesterone (1)
  • SHP2 (1)
  • SMAD2 (1)
  • Testosterone (1)
  • TSH (4)
Application
  • Protein Analysis & Detection (83)
Therapeutic Area
  • Angiogenesis (1)
  • Biologics/Bioprocess (4)
  • Cancer (2)
  • Inflammation (4)
  • Metabolic (61)
  • Metabolism (3)
  • Oncology (1)
Product Brand Name
  • Alpha SureFire Ultra Multiplex (2)
  • AlphaLISA (49)
  • AlphaLISA SureFire Ultra (2)
  • AlphaPlex (2)
  • LANCE Ultra (28)
  • Membrane Target Systems (1)
  • NEN Radiochemicals (39)
  • Quantum (1)
Detection Method
  • Alpha (56)
  • Radiometric (40)
  • Time-Resolved Fluorescence (TRF) (25)
  • TR-FRET (25)
Receptor Type
  • Ghrelin (1)
Assay Validated
  • Binding (1)
Radioisotope
  • C-14 (22)
  • H-3 (18)
Radionuclide
  • 14C (22)
  • 3H (18)
Label Position
  • Generally Labeled (1)
  • Nominally Labeled (12)
  • Specifically Labeled (18)
  • Uniformly Labeled (9)
Assay Points (200-50,000)
  • 100 (31)
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  • 500 (58)
  • 5000 (38)
  • 50000 (5)
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  • Cytokine (1)
  • GPCR (1)
  • Hormone (35)
  • Peptide (4)
  • Phosphoprotein (3)
  • Protein (45)
Automation Compatible
  • Yes (85)
Concentration
  • 0.02 mCi/mL (1)
  • 0.05 mCi/mL (1)
  • 0.1 mCi/mL (9)
  • 0.2 mCi/mL (4)
  • 1 mCi/mL (13)
Experimental Type
  • In vitro (73)
Format
  • Microplates (63)
Host Cell
  • CHO-K1 (1)
Imaging Modality
  • microCT Imaging (1)
Volume
  • 0-50 (10)
  • 201-250 (4)

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1-25 of 130 Products & Services

  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT Imaging System

    Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
  • AlphaLisa Analyte 2

    Corticosterone (human), liquid (AlphaLISA)

    Human corticosterone standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human Corticosterone Detection Kit, but can also be ordered separately.
    List Price : 278.00 USD
  • AlphaLISA assay principle

    MANF (human) AlphaLISA Detection Kit

    The AlphaLISA? immunoassay kit for human MANF enables the quantitative determination of mesencephalic astrocyte-derived neurotrophic factor (MANF) in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 736.00 USD - 22100.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Glucose, D-[1-14C]

    D-glucose, labeled with C-14. D-glucose can be incorporated into lipds, and provides a measurement of glucose transport. It is a metabolized tracer in glucose uptake studies.
    Price Range : 824.00 USD - 4649.00 USD
  • Adenosine 5 Triphosphate 250 μCi

    Mannitol, D-[1-3H(N)]

    D-mannitol, labeled with tritium at C1. Tritiated manitol is commonly used as an extracellular space marker.
    Price Range : 682.00 USD - 1272.00 USD
  • Alpha SureFire Ultra Multiplex kits

    Alpha SureFire Ultra Multiplex Phospho/Total SMAD2 Assay Kit

    The AlphaLISA? SureFire? Ultra? Multiplex phospho-SMAD2 (Ser465/467) + Total SMAD2 assay kit is used to measure both the phosphorylation of SMAD2 and total levels of endogenous SMAD2 in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure SMAD2 phosphorylation by either recombinant or endogenous receptors and can be applied to primary cells.
    Price Range : 946.00 USD - 60600.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Glucosamine, N-Acetyl-D - [1-14C]

    50 μCi quantities of N-Acetyl-D-[1-14C]-Glucosamine are available for your research.
    List Price : 2399.00 USD
  • Adenosine 5 Triphosphate 250 μCi

    Deoxy-D-glucose, 2-[1,2-3H (N)]-, EtOH Sol, Specific Activity: 5-10 Ci (185-370 GBq)/mmol

    2-Deoxy-D-glucose, nominally labeled with tritium at C1/C2. This product is supplied in 90% ethanol. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.
    Price Range : 840.00 USD - 1315.00 USD
  • Deoxy-D-glucose, 2-[14C(U)]

    2-Deoxy-D-glucose, labeled uniformly with carbon-14. This product is supplied steri-packaged in an aqueous solution. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.
    Price Range : 1182.00 USD - 2922.00 USD
  • Alpha SureFire Ultra Multiplex kits

    Alpha SureFire Ultra Multiplex phospho/total AMPKα1/2 Assay Kit

    The Alpha SureFire? Ultra? Multiplex phospho AMPKα1/2 (Thr172) + Total AMPKα1/2 assay kit is used to measure both the phosphorylation (on Thr172) and total levels of endogenous AMPKα1/2 in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure AMPKα1/2 phosphorylation by either recombinant or endogenous receptors and can be applied to primary cells.

  • AlphaLISA immunoassay kits

    hCG (human) AlphaLISA Detection Kit

    The AlphaLISA? immunoassay kit for human chorionic gonadotropin (hCG) enables the quantitative determination of hCG in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 619.00 USD - 18600.00 USD
  • AlphaLISA immunoassay kits

    Adiponectin (human) AlphaLISA Detection Kit

    The AlphaLISA? Human Adiponectin Detection Kit is designed for detection and quantitation of human adiponectin in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 1811.00 USD - 12000.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Inulin, Carboxyl-, [Carboxyl-14C]

    Inulin-carboxyl, labeled on carboxyl groups with C-14. Inulin-carboxyl-14C is commonly used in renal cearance studies.
    Price Range : 661.00 USD - 3279.00 USD
  • Protein

    Glucagon (human), liquid (LANCE)

    Human glucagon standard, liquid, for use in running standard curves in LANCE TR-FRET no-wash detection assays. This standard is already provided in the LANCE Ultra Human Glucagon TR-FRET Detection Kit, but can be ordered separately.
    List Price : 261.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Deoxy-D-glucose, 2-[1-14C]-, Aqueous Sol, Specific Activity: 45-60 mCi (1.66-2.22 GBq)/mmol,>97%

    2-Deoxy-D-glucose, labeled with carbon-14 at C1. This product is supplied steri-packaged in an aqueous solution. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.
    Price Range : 1303.00 USD - 5200.00 USD
  • Protein

    IGF-1 (rat), lyophilized (LANCE)

    Rat IGF-1 (insulin-like growth factor 1) standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra rat IGF-1 Detection Kit, but can also be ordered separately.
    List Price : 321.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Deoxy-D-glucose, 2-[1-14C]-, EtOH Sol, Specific Activity: 45-60 mCi (1.66-2.22 GBq)/mmol,>97%

    2-Deoxy-D-glucose, labeled with carbon-14 at C1. This product is supplied in 90% ethanol. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.
    Price Range : 1303.00 USD - 5900.00 USD
  • AlphaLISA immunoassay kits

    LDHA (human) AlphaLISA Detection Kit

    The AlphaLISA? immunoassay kit for human lactate dehydrogenase subunit A (LDHA) enables the quantitative determination of human LDHA in cell lysates and serum using a homogeneous AlphaLISA assay (no wash steps). Please note this is NOT a cell cytotoxicity assay, as the assay does not measure secreted LDH.
    Price Range : 867.00 USD - 16700.00 USD
  • AlphaLisa Analyte 2

    IGF-1 (rat), lyophilized (AlphaLISA)

    Rat IGF-1 standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA Rat IGF-1 Detection Kit, but can also be ordered separately.
    List Price : 352.00 USD
  • AlphaLisa Analyte 2

    ApoB (human), lyophilized (AlphaLISA)

    Human ApoB standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human ApoB Detection Kit, but can also be ordered separately.
    List Price : 352.00 USD
  • AlphaLISA immunoassay kits

    AST (human) AlphaLISA Detection Kit

    The AlphaLISA? immunoassay kit for human AST enables the quantitative determination of human aspartate transaminase (AST) in buffered solution, cell culture media, and serum using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 867.00 USD - 16700.00 USD
  • AlphaPlex Samarium immunoassay kits

    AlphaPlex-645 (Sm) Human Insulin Detection Kit

    The AlphaPlex? 645 (Samarium) Human Insulin Detection Kit is designed for the quantitative determination of human insulin together with another analyte (AlphaLISA) in serum, buffered solution or cell culture medium using a homogeneous (no wash steps, no separation steps) assay.
    Price Range : 549.00 USD - 12000.00 USD
  • AlphaLISA immunoassay kits

    Insulin (human) AlphaLISA Detection Kit

    The AlphaLISA? Human Insulin Detection Kit is designed for detection and quantitation of human insulin in cell culture supernatants, serum, and plasma using a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 828.00 USD - 11600.00 USD
  • AlphaLISA immunoassay kits

    Heme oxygenase 2 AlphaLISA Detection Kit

    The AlphaLISA? immunoassay kit for human heme oxygenase 2 (HO-2) enables the quantitative determination of human HO-2 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 515.00 USD - 11300.00 USD
  • AlphaLISA immunoassay kits

    Cortisol (human) AlphaLISA Detection Kit

    AlphaLISA no-wash immunoassay kit for detection of human cortisol in buffer or serum.
    Price Range : 829.00 USD - 12000.00 USD
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